DMT Freebase Content in Ayahuasca/Pharmahuasca Preparations
Jun 2003
Due to the lack of information as to dosages and the correlation between DMT Freebase and potential pharmahuasca preparations, this information has been prepared. This document does not discuss the 2-3 gms of syrian rue or B. cappi vine Mao inhibitors that are necessary for activation, which are described elsewhere on the net.
From Shulgin in Tikhal we find that he had no success in crystallizing the Hydrochloride salt of the free base (HCl) . Therefore the weight of material may be assumed to be the freebase and Mole adjustment of amounts for the HCl salt should not be necessary. (The m.p. range for the freebase is 47-67 deg. C and the HCl salt is reported to be 167deg C. A m.p. test may be run if there are any questions. ).
The methodology took the average DMT dose from Ott's Tables in Ayahuasca Analogs. The values in these potions matched the bio-assay amounts done on Syrian Rue / Psychotria Viridis mixtures.
In table C of Ott's work Ayahuasca Analogs we find the following Analysis:
From this table it can be seen that the average dose when potentiated by the MAO-B inhibitors found in the Harmaline alkaloids, is 29 mgs.
Based upon an average analysis of the potency of the Psychotria Viridis of .20% /gram of DMT, then a dosage of 15grams of dried leaf would give approximately 30 mgs of DMT. This amount was found to do nicely bio-assay with a 6 hour total journey time.
Analysis of the Mimosa Hostilis rootbark (MHRB) amounts recommended (8 gms) when correlated with the amount of DMT found in the rootbark (average .57%) gives a total dosage of 45 mgs of DMT in the potion. Given that reports of MHRB journeys are typically more intense, this would correlate well with the higher doses.
Based upon the Bio-Assay results, Ott's Reports, and the Anecdotal Trip report recommendations, the amount of pure N,N-DimethylTryptamine to use in an initial Pharmahuasca preparation would be 30 mgs. Boosters of 15 mgs may be utilized on the downside of the peak to extend and re-energize the journey. Of course experienced psychonauts adjust there dosages according to their personal reactions, biological idiosyncracies and desired effects levels.
From Shulgin in Tikhal we find that he had no success in crystallizing the Hydrochloride salt of the free base (HCl) . Therefore the weight of material may be assumed to be the freebase and Mole adjustment of amounts for the HCl salt should not be necessary. (The m.p. range for the freebase is 47-67 deg. C and the HCl salt is reported to be 167deg C. A m.p. test may be run if there are any questions. ).
The methodology took the average DMT dose from Ott's Tables in Ayahuasca Analogs. The values in these potions matched the bio-assay amounts done on Syrian Rue / Psychotria Viridis mixtures.
In table C of Ott's work Ayahuasca Analogs we find the following Analysis:
| Table II-C--Reported Analyses of Ayahuasca Potions | |||
|---|---|---|---|
| Source | # Samples | Beta-Carbolines | DMT |
| Der Marderosian et al 1970 | 1 | 20 mg | 30 mg |
| Rivier & Lindgren 1972 | 9 | 40 mg | 25 mg |
| McKenna et al 1984 | 5 | 401 mg | 36 mg |
| Liwszyc et al 1992 | 1 (Santo Daime) | 144 mg | 26 mg |
| === | ========== | ========= | |
| Overall Average | 16 | 158 mg | 29 mg |
From this table it can be seen that the average dose when potentiated by the MAO-B inhibitors found in the Harmaline alkaloids, is 29 mgs.
Based upon an average analysis of the potency of the Psychotria Viridis of .20% /gram of DMT, then a dosage of 15grams of dried leaf would give approximately 30 mgs of DMT. This amount was found to do nicely bio-assay with a 6 hour total journey time.
Analysis of the Mimosa Hostilis rootbark (MHRB) amounts recommended (8 gms) when correlated with the amount of DMT found in the rootbark (average .57%) gives a total dosage of 45 mgs of DMT in the potion. Given that reports of MHRB journeys are typically more intense, this would correlate well with the higher doses.
Based upon the Bio-Assay results, Ott's Reports, and the Anecdotal Trip report recommendations, the amount of pure N,N-DimethylTryptamine to use in an initial Pharmahuasca preparation would be 30 mgs. Boosters of 15 mgs may be utilized on the downside of the peak to extend and re-energize the journey. Of course experienced psychonauts adjust there dosages according to their personal reactions, biological idiosyncracies and desired effects levels.
Related Documents