5-MAPB is a synthetic empathogenic stimulant that is most often found in powder form and taken orally, nasally, or rectally. IM and IV use have been reported. Although there's a wide range of reported doses reported, often this is related to differences in expectations for effects. 5-MAPB is considered slightly more potent than MDMA (but less stimulating), on a milligram per milligram basis, with perhaps 50-70mg of 5-MAPB being the equivalent of 100mg of MDMA. Because Erowid has read less than 40 total human reports of 5-MAPB use (as of Oct 2014), dose ranges are tentative.

Some other information sources suggest that 100 mg is a "normal" dose, but the effects reported at this or higher doses are often very strong and the negative side-effects more prominent. 5-MAPB may not be suited to those seeking strong stimulation, as the doses required to achieve strong stimulation are quite high.

Several batches of 5-MAPB sold between 2013 and 2015 have included 5- or 6-EAPB and doses of the -EAPB versions appear to be lower, making some reported doses of 5-MAPB higher than they would be with pure 5- or 6-MAPB.

Note that insufflanting 5- or 6-MAPB can be more likely to result in unpleasantly strong effects or over doses.